Assessing Research Results in the Medical Literature Trust but Verify
Clinical research should contribute to a generalizable body of evidence that can guide decisions about clinical practice, personal health, and health policies. Recently, however, the integrity of the...
View ArticleTrust in the Medical Literature—and Viewpoints in JAMA Internal Medicine...
The mission of JAMA Internal Medicine is to publish high-quality scientific articles that inform medical practice, health care, and health policy. In this issue, we publish 3 articles on the theme of...
View ArticleEfficacy to Effectiveness—Reply Letters
In Reply The comment by Pagoto and Lemon raises several important considerations articulated well by others relating to the design, conduct, and reporting of clinical research studies to better inform...
View ArticleIncorrect Information in Text
In the Original Investigation titled “Characteristics of Oncology Clinical Trials: Insights From a Systematic Analysis of ClinicalTrials.gov,” published online on April 29 and also in the June 10 issue...
View ArticleSecondary Use of Health Information Are We Asking the Right Question?
The implementation and deployment of electronic health records on a national scale continues to be an arduous and expensive process. Although there is still controversy as to whether the use of...
View ArticlePresenting Quantitative Information About Placebo Rates to Patients
Research suggests that many people do not know the purpose of placebo groups in experiments and do not adequately understand the concept of clinical trial informed consent. However, people may be able...
View ArticleA Comparison of Results of the US Food and Drug Administration’s...
The US Food and Drug Administration (FDA) recently started an initiative called “Mini-Sentinel Program” to assess medical product safety using administrative-observational databases. One of the first...
View ArticleCan Expedited FDA Drug Approval Without Expedited Follow-up Be Trusted?
Like blood itself flowing through the human circulatory network, several billion prescriptions and hundreds of billions of drugs course every year through the vast web of factories, wholesale...
View ArticleInterpreting Treatment Effects From Clinical Trials in the Context of...
ImportanceOlder adults are often excluded from clinical trials. The benefit of preventive interventions tested in younger trial populations may be reduced when applied to older adults in the clinical...
View ArticleClinical Trial Evidence and Use of Fish Oil Supplements
Randomized clinical trials (RCTs) with “hard” end points and meta-analyses of these trials should influence clinical practice because they represent the highest level of evidence. Health care behaviors...
View ArticleRepresentation of Women as Authors of Collaborative Cancer Clinical Trials
Team-based research in medicine is common. Simultaneously, women’s role in the medical profession has grown, including the representation of women as authors of academic publications. We studied the...
View ArticleInformed Consent in Randomized Quality Improvement Trials A Critical Barrier...
The widespread implementation of electronic medical records (EMRs), stimulated by the Patient Protection and Affordable Care Act, provides a major opportunity to conduct inexpensive pragmatic...
View ArticleMedicine’s Uncomfortable Relationship With Math Calculating Positive...
In 1978, Casscells et al published a small but important study showing that the majority of physicians, house officers, and students overestimated the positive predictive value (PPV) of a laboratory...
View ArticleDescriptions and Interpretations of the ACCORD-Lipid Trial in the News and...
The lipid component of the Action to Control Cardiovascular Risk in Diabetes (ACCORD-Lipid) trial was a landmark, publicly funded study demonstrating that fenofibrate, when added to statin therapy, was...
View ArticleA Guide to Reading Health Care News Stories
From April 16, 2006, through May 30, 2013, a team of reviewers from HealthNewsReview.org, many of whom were physicians, evaluated the reporting by US news organizations on new medical treatments,...
View ArticleLitigation Seeking Access to Data From Ongoing Clinical Trials A Threat to...
Researchers conducting randomized clinical trials may find themselves subject to legal subpoenas for interim data. When a subpoena demands premature disclosure of unblinded data, there is potential for...
View ArticleClinical Trials and the Right to Remain Silent
In this issue of JAMA Internal Medicine, Kernan et al chronicle Yale University’s experience responding to a subpoena for data from an ongoing, double-blind, placebo-controlled trial of pioglitazone....
View ArticlePublication of Pivotal Efficacy Trials for Novel Therapeutic Agents Approved...
Pivotal efficacy trials, which are trials that form the basis of the US Food and Drug Administration’s (FDA) decision to approve a novel therapeutic agent, have great relevance to clinical practice...
View ArticleLitigation Seeking Access to Data From Ongoing Clinical Trials A Threat to...
Researchers conducting randomized clinical trials may find themselves subject to legal subpoenas for interim data. When a subpoena demands premature disclosure of unblinded data, there is potential for...
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